The Prostate Sarcoma – A Diagnostic Challenge Initially Suspected as Prostatitis

Authors

  • David Weiss Department of Diagnostic and Interventional Radiology University Medicine Oldenburg, Carl von Ossietzky Universität Oldenburg, Oldenburg, Klinikum Oldenburg, Rahel-Straus-Str. 10, 26133 Oldenburg, Germany https://orcid.org/0009-0004-8717-6208
  • Arne Bischoff Department of Diagnostic and Interventional Radiology, University Medicine Oldenburg, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany https://orcid.org/0009-0006-9027-0638
  • Tariq Takla Department of Urology, University Medicine Oldenburg, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany https://orcid.org/0009-0006-2134-6491
  • Verena Mack Department of Diagnostic and Interventional Radiology, University Medicine Oldenburg, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany https://orcid.org/0000-0002-3173-4686
  • Martin Maurer Department of Diagnostic and Interventional Radiology University Medicine Oldenburg, Carl von Ossietzky Universität Oldenburg, Oldenburg, Klinikum Oldenburg, Rahel-Straus-Str. 10, 26133 Oldenburg, Germany https://orcid.org/0000-0003-0153-3987

DOI:

https://doi.org/10.59667/sjoranm.v20i1.16

Keywords:

Prostatic sarcoma, infiltrative unstable, partially CD34 + sarcoma, atypical or refractory urological symptoms

Abstract

Prostatic sarcomas are rare and aggressive malignancies, often presenting with nonspecific symptoms that mimic benign urological conditions, potentially leading to diagnostic delays [1]. This case outlines the clinical course of a 42-year-old male with a prostatic sarcoma, emphasizing the importance of early imaging, histopathological assessment, and multidisciplinary oncological management. This case underscores the importance of maintaining a high index of suspicion in patients with atypical or refractory urological symptoms. It also highlights the critical role of a multidisciplinary approach, encompassing urology, oncology, radiology, and pathology, in managing such rare malignancies. Ultimately, the case emphasizes the ongoing need for novel and more effective systemic therapies to improve outcomes.

References

1) Herlemann A, Horst D, D’Anastasi M, Kretschmer A, Stief CG, Gratzke C. Das primäre Prostatasarkom – ein seltenes Malignom. Der Urologe. 2017 Mar 27;56(7):857–60.

https://doi.org/10.1007/s00120-017-0370-z

2) Alfaro-Cervelló C, Nieto G, Navarro S. Differential diagnosis of myxoid soft tissue tumors. Experience in the Clinical University Hospital of Valencia. Revista Española de Patología [Internet]. 2019 Nov 4;55(3):185–91.

https://doi.org/10.1016/j.patol.2019.07.005

3) Yang W, Liu A, Wu J, Niu M. Prostatic stromal sarcoma. Medicine. 2018 May;97(18):e0495.

https://doi.org/10.1097/MD.0000000000010495

4) Steen ST, Stephenson GR. Current Treatment of Soft Tissue Sarcoma. 2008 Oct 1:

https://doi.org/10.1080/08998280.2008.11928435

5) Guidelines Chemotherapy for Soft Tissue Sarcomas [Internet]. 2025 www.cancer.org.

https://www.cancer.org/cancer/types/soft-tissue-sarcoma/treating/chemotherapy.html

6) Maki RG. Gemcitabine and Docetaxel in Metastatic Sarcoma: Past, Present, and Future. The Oncologist. 2007 Aug 1;12(8):999–1006. https://doi.org/10.1634/theoncologist.12-8-999

7) Soft tissue sarcoma survival [Internet]. Sarcoma UK. 2024 [cited 2025 Apr 21].

https://sarcoma.org.uk/about-sarcoma/soft-tissue-sarcoma-data-hub/soft-tissue-sarcoma-survival/

Prostate Sarcoma

Published

2025-06-20

Data Availability Statement

All data generated or analyzed during this study are available from the corresponding author upon reasonable request. The datasets supporting the conclusions of this article have been securely archived and can be accessed for further assessment, subject to ethical and legal considerations. This work has been published in the Swiss Journal of Radiology and Nuclear Medicine.

How to Cite

The Prostate Sarcoma – A Diagnostic Challenge Initially Suspected as Prostatitis. (2025). Swiss Journal of Radiology and Nuclear Medicine, 20(1), 31-35. https://doi.org/10.59667/sjoranm.v20i1.16