A Characteristic but Rare Skeletal Scintigraphy Findings in Sickle Cell Disease

A Case Report

Authors

  • Dr. Parth Bambhroliya All India Institute of Medical Sciences, Bhubaneswar, India https://orcid.org/0009-0000-5115-1317
  • Dr. T Kishan Subudhi All India Institute of Medical Sciences, Bhubaneswar, India
  • Dr. Subhaditya Basu All India Institute of Medical Sciences, Bhubaneswar, India
  • Dr. Girish Kumar Parida All India Institute of Medical Sciences, Bhubaneswar, India
  • Dr. P Sai Sradha Patro All India Institute of Medical Sciences, Bhubaneswar, India
  • Dr. Kanhaiyalal Agrawal All India Institute of Medical Sciences, Bhubaneswar, India

DOI:

https://doi.org/10.59667/sjoranm.v28i1.18

Keywords:

sickle cell disease , bone scan, splenic uptake

Abstract

Sickle cell disease is associated with recurrent vaso-occlusive episodes leading to a wide spectrum of skeletal complications. We report a case of a 39-year-old male with sickle cell disease who underwent bone scintigraphy for evaluation of right hip pain following bilateral hip arthroplasty. The study demonstrates various characteristic skeletal scintigraphy findings in sickle cell disease and emphasizes the diagnostic value of bone scintigraphy in identifying skeletal manifestations of the disease.

References

1. Almeida A, Roberts I. Bone involvement in sickle cell disease. Br J Haematol. 2005 May;129(4):482–90. https://doi.org/10.1111/j.1365-2141.2005.05476.x

2. Sakellariou K, Charalampidou S, Fotopoulos A, Sioka C. Hybrid bone SPECT/CT reveals spleen calcification in sickle cell mutation and beta-thalassemia. Nucl Med Rev. 2022 Jan 31;25(1):70–1. https://doi.org/10.5603/nmr.a2021.0015

3. Parida G, Mitra S, Muthu G, Suman A. Rare case of diffuse splenic uptake on methylene diphosphonate bone scan in a patient with sickle cell disease. Indian J Nucl Med. 2020;35(2):162. https://doi.org/10.4103/ijnm.ijnm_187_19

4. Franceschi D, Nagel JS, Holman BL. Splenic Accumulation of Technetium-99m-Methylene Diphosphonate in a Transfusion-Dependent Patient with Chronic Myelogenous Leukemia. J Nucl Med. 1990 Sept 1;31(9):1552.

5. Ganguly A, Boswell W, Aniq H. Musculoskeletal Manifestations of Sickle Cell Anaemia: A Pictorial Review. Anemia. 2011;2011:1–9.N https://doi.org/10.1155/2011/794283

6. Cerci SS, Suslu H, Cerci C, Yildiz M, Ozbek FM, Balci TA, et al. Different findings in Tc-99m MDP bone scintigraphy of patients with sickle cell disease: report of three cases. Ann Nucl Med. 2007 July 25;21(5):311–4. https://doi.org/10.1007/s12149-007-0025-z

article_cover

Published

2026-02-26

Data Availability Statement

Contact the corresponding author for data requests. 

How to Cite

A Characteristic but Rare Skeletal Scintigraphy Findings in Sickle Cell Disease: A Case Report. (2026). Swiss Journal of Radiology and Nuclear Medicine, 28(1), 15-18. https://doi.org/10.59667/sjoranm.v28i1.18

Share

Similar Articles

1-10 of 47

You may also start an advanced similarity search for this article.