⁶⁸Ga-DOTATATE PET/CT Findings in Suspected Tumor-Induced Osteomalacia

A Prospective Descriptive Study

Authors

DOI:

https://doi.org/10.59667/sjoranm.v24i1.18

Keywords:

tumor-induced osteomalacia, phosphaturic mesenchymal tumors, 68Ga-DOTATATE, positron emission tomography, computed tomography

Abstract

Objective. To describe ⁶⁸Ga-DOTATATE PET/CT findings and their relationship to available histopathology in patients referred for suspected tumor-induced osteomalacia. Methods. This prospective descriptive study included 18 patients evaluated at a referral center in Argentina. Results. The median age was 47.5 years and 13 of 18 patients were women. The reported median SUVmax was 17.2 (interquartile range 6.27–30.6). Lesions were most frequently reported in the appendicular skeleton. Eight patients had histologically confirmed phosphaturic mesenchymal tumors (PMTs). Two of these eight patients had lesions with ill-defined margins and involvement of soft tissue and facial bones. Median SUVmax was numerically higher in the PMT group. The difference was not statistically significant as reported. Conclusion. In this referral cohort, ⁶⁸Ga-DOTATATE PET/CT helped localize and characterize lesions in patients with suspected tumor-induced osteomalacia. Confirmed PMTs showed variable morphology. The findings support descriptive interpretation in conjunction with histopathology and clinical assessment.

Author Biographies

  • Prof. Dr. María Bastianello, MD PhD, Molecular Imaging and Metabolic Therapy, Hospital Universitario CEMIC, Buenos Aires, Argentina

    Professor and Head of Division of Molecular Imaging and Metabolic Therapy, Hospital Universitario CEMIC, Buenos Aires, Argentina

    Argentina Tumor-Induced Osteomalacia Study Group, Buenos Aires, Argentina

  • Roxana Chirico, Molecular Imaging and Metabolic Therapy, Hospital Universitario CEMIC, Buenos Aires, Argentina

    Medica Especialista en Medicina Nuclear. Coordinadora de la Carrera Especialista en Imagenes Moleculares y Terapia . CEMIC. IUC.UNSAM Docente IUC y UNSAM, Buenos Aires, Argentina

    Molecular Imaging and Metabolic Therapy, Hospital Universitario CEMIC, Buenos Aires, Argentina

    Argentina Tumor-Induced Osteomalacia Study Group, Buenos Aires, Argentina

  • Matías Cimín, Molecular Imaging and Metabolic Therapy, Hospital Universitario CEMIC, Buenos Aires, Argentina

    Medico Especialista en Medicina Nuclear y Medico de planta de la Seccion de imagenes moleculares y terapia metabolica en CEMIC, Buenos Aires, Argentina

    Molecular Imaging and Metabolic Therapy, Hospital Universitario CEMIC, Buenos Aires, Argentina

    Argentina Tumor-Induced Osteomalacia Study Group, Buenos Aires, Argentina

  • María Belén Zanchetta, Institute of Metabolic Diagnosis and Research (IDIM), Buenos Aires, Argentina

    Professor of Bone Disordes at the University of Salvador and is the Medical Director of the Institute of Metabolic Diagnosis and Research (IDIM)

References

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SJORANM article cover, Vol. 24 No. 1 (2025). Holographic symbolic illustration for article 87.

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Published

2025-10-31

Data Availability Statement

The datasets generated during the current study are available from the corresponding author on reasonable request.

Issue

Vol. 24 No. 1 (2025)

Section

Research Articles

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Copyright (c) 2025 Prof. Dr. María Bastianello, MD PhD, Roxana Chirico, Matías Cimín, María Belén Zanchetta

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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How to Cite

Bastianello, M., Chirico, R., Cimín, M., & Zanchetta, M. B. (2025). ⁶⁸Ga-DOTATATE PET/CT Findings in Suspected Tumor-Induced Osteomalacia: A Prospective Descriptive Study. Swiss Journal of Radiology and Nuclear Medicine, 24(1), 15-21. https://doi.org/10.59667/sjoranm.v24i1.18

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