Metastatic Malignant Peripheral Nerve Sheath Tumor: Imaging Findings in a Case Report

Authors

DOI:

https://doi.org/10.59667/sjoranm.v15i1.12

Keywords:

MPNST, NERVE SHEATH TUMOR, METASTATIC, FDG, PETCT

Abstract

A 28-year-old woman with a history of acoustic neuroma presented with six months of progressive dorsolumbar pain, occasional lower-limb numbness and mild weakness. MRI demonstrated an invasive heterogeneous paraspinal mass extending along the nerve roots. Biopsy showed findings consistent with malignant peripheral nerve sheath tumor (MPNST). FDG PET/CT demonstrated uptake in the primary mass and pulmonary nodules considered metastatic on imaging. The primary tumor was considered unresectable, and chemotherapy and radiotherapy were initiated. This case illustrates the complementary roles of tissue diagnosis, MRI and FDG PET/CT in the assessment of MPNST with suspected pulmonary metastases.

Author Biographies

  • Ritesh Suthar, Department of Nuclear Medicine, The Gujarat Cancer and Research Institute, Ahmedabad, India

    Assistant Professor, Department of Nuclear Medicine 

  • Abhishek Palsapure, Department of Nuclear Medicine, The Gujarat Cancer and Research Institute, Ahmedabad, India

    Senior Resident, Department of Nuclear Medicine

  • Jahnavi Gandhi, Department of Oncopathology, The Gujarat Cancer and Research Institute, Ahmedabad, India

    Assistant Professor, Department of Oncopathology

References

Geitenbeek RTJ, Martin E, Graven LH, et al. Diagnostic value of 18F-FDG PET-CT in detecting malignant peripheral nerve sheath tumors among adult and pediatric neurofibromatosis type 1 patients. J Neurooncol. 2022;156(3):559–567. https://doi.org/10.1007/s11060-021-03936-y DOI: https://doi.org/10.1007/s11060-021-03936-y

Kar M, Deo SVS, Shukla NK, et al. Malignant peripheral nerve sheath tumors (MPNST) – Clinicopathological study and treatment outcome of twenty-four cases. World J Surg Oncol. 2006;4:55. https://doi.org/10.1186/1477-7819-4-55 DOI: https://doi.org/10.1186/1477-7819-4-55

SJORANM article cover: Peripheral nerve sheath tumor. Vol. 15 No. 1, January 2025. Holographic symbolic illustration.

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Published

2025-01-29

Issue

Vol. 15 No. 1 (2025)

Section

Case reports

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Copyright (c) 2025 Saloni Rajkotia, Ritesh Suthar, Abhishek Palsapure, Jahnavi Gandhi

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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How to Cite

Rajkotia, S., Suthar, R., Palsapure, A., & Gandhi, J. (2025). Metastatic Malignant Peripheral Nerve Sheath Tumor: Imaging Findings in a Case Report. Swiss Journal of Radiology and Nuclear Medicine, 15(1), 1-4. https://doi.org/10.59667/sjoranm.v15i1.12

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