A Nasopharyngeal Metastasis of Papillary Thyroid Carcinoma
An Unusual Site of Distant Metastasis: A Case Report
DOI:
https://doi.org/10.59667/sjoranm.v10i1.14Keywords:
Nasopharynx, papillary thyroid carcinoma, thyroidectomy, radiotherapy, distant metastasisAbstract
Background: Papillary thyroid carcinoma (PTC) despite of an indolent clinical behavior is known to cause locoregional recurrence and distant metastasis. Lung and bone are the common site of distant metastasis. Nasopharynx is a very rare site of metastasis.
Methods: Case report
Results: A case is discussed in which patient was diagnosed with PTC and had undergone total thyroidectomy with lymph node dissection with subsequent radiotherapy. Patient presented with nasopharyngeal metastasis within 3 years of diagnosis.
Conclusion: Classic PTC can cause recurrence in the form of metastasis in distant rare sites including nasopharynx. It is necessary to keep patients in regular frequent follow-up after initial management especially when associated with high risk factors.
References
Ito, Yasuhiro, et al. "Overall survival of papillary thyroid carcinoma patients: a single-institution long-term follow-up of 5897 patients." World journal of surgery 42 (2018): 615-622. https://doi.org/10.1007/s00268-018-4479-z
Ulisse, Salvatore, et al. "Papillary thyroid cancer prognosis: An evolving field." Cancers 13.21 (2021): 5567. https://doi.org/10.3390/cancers13215567
Toraih, Eman A., et al. "Site-specific metastasis and survival in papillary thyroid cancer: the importance of brain and multi-organ disease." Cancers 13.7 (2021): 1625. https://doi.org/10.3390/cancers13071625
Maocai, Li, et al. "Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report." Medicine 99.33 (2020): e21599. https://doi.org/10.1097/MD.0000000000021599
Coca-Pelaz, Andrés, et al. "Papillary thyroid cancer — Aggressive variants and impact on management: A narrative review." Advances in therapy 37 (2020): 3112-3128. https://doi.org/10.1007/s12325-020-01391-1
WHO Classification of Tumours Editorial Board. Endocrine and neuroendocrine tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2022 [cited 2024 Mar 28]. (WHO classification of tumours series, 5th ed.; vol. 10). Available from: https://tumourclassification.iarc.who.int/chapters/53.
Jukić, Tomislav, et al. "Long-term outcome of differen-tiated thyroid cancer patients — Fifty years of Croatian thyroid disease referral centre experience." Diagnostics 12.4 (2022): 866. https://doi.org/10.3390/diagnostics12040866
Wu, Tong, et al. "Brain metastases from differentiated thyroid carcinoma: a retrospective study of 22 patients." Frontiers in Endocrinology 12 (2021): 730025. https://doi.org/10.3389/fendo.2021.730025
Bashank, Nahla, et al. "Rare sites of metastases in patients with differentiated thyroid carcinoma and added value of SPECT/CT over planar whole body radioactive iodine scan." European Journal of Hybrid Imaging 6.1 (2022): 34. https://doi.org/10.1186/s41824-022-00155-0
Patel, Trupti Shreyans, et al. "Nasopharyngeal metastasis of follicular carcinoma of the thyroid with extensive clear cell change: a case report." Ear, Nose & Throat Journal 91.12 (2012): E16-E18.https://doi.org/10.1177/014556131209101216
Limpawittayakul, Piyarat, and Numfon Sinchai. "Unusual presentation of papillary thyroid carcinoma nasopharyngeal metastasis: case report." The Journal of Chulabhorn Royal Academy 1.1 (2019): 30-36.
Xu, Anqi, et al. "Solitary Nasopharyngeal Metastasis From Papillary Thyroid Carcinoma Shown on FDG PET/CT." Clinical Nuclear Medicine 47.5 (2022): e425-e427. https://doi.org/10.1097/RLU.0000000000004095
Tian, Linli, et al. "Ectopic thyroid papillary carcinoma of nasopharynx associated with adenoid hypertrophy: an unusual presentation." Head & Face Medicine 10 (2014): 1-4. https://doi.org/10.1186/1746-160X-10-40
Lai, Yuting, et al. "Low-grade nasopharyngeal papillary adenocarcinoma: a review of 28 patients in a single institution." Cancer Management and Research (2021): 1271-1278 . www.tandfonline.com/journals/dcmr20
Lee, Anna, James CH Chow, and Nancy Y. Lee. "Treatment deescalation strategies for nasopharyngeal cancer: a review." JAMA oncology 7.3 (2021): 445-453. https://doi.org/10.1001/jamaoncol.2020.6154
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Biren Parikh Parikh, Nair Tara, Ritesh R Suthar, Deepa Nagarajan, Priti P Trivedi
This work is licensed under a Creative Commons Attribution 4.0 International License.
This license requires that reusers give credit to the creator. It allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, even for commercial purposes.
