Artificial Neural Networks for Breast Cancer Risk Prediction: Model Architecture and Reported Performance
DOI:
https://doi.org/10.59667/sjoranm.v18i1.16Keywords:
Artificial Neural Networks (ANNs), Predictive analytics, Breast cancer, Risk factors, Personalized preventionAbstract
Introduction: This article examines the use of artificial neural networks (ANNs) to model breast cancer risk from genetic, hormonal, lifestyle and environmental factors.
Methodology: The described workflow includes data preprocessing, an 80/10/10 training–validation–test split, a neural network with three hidden layers of 64, 32 and 16 neurons, and a sigmoid output. The article describes cross-validation, external testing and SHAP-based interpretation of model predictions.
Results and Discussion: The reported performance measures are accuracy 85%, precision 0.82, recall 0.87, F1-score 0.84 and AUC–ROC 0.91. The discussion considers model interpretability, data quality and class imbalance. These measures summarize the reported classification performance; they do not establish improved patient outcomes or superiority to radiologists or alternative models.
Conclusion: ANN-based modelling may support further research on breast cancer risk prediction. The reported results should be interpreted as model performance measures rather than evidence of clinical benefit. Further validation is required before clinical implementation.
References
1. World Health Organization. (2021). Breast cancer: Key facts. Retrieved from https://www.who.int/news-room/fact-sheets/detail/breast-cancer
2. Momenimovahed, Z., & Salehiniya, H. (2019). Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer: Targets and Therapy, 11, 151-164. https://doi.org/10.2147/BCTT.S176070 DOI: https://doi.org/10.2147/BCTT.S176070
3. Rabiei R, Ayyoubzadeh SM, Sohrabei S, Esmaeili M, Atashi A. Prediction of Breast Cancer using Machine Learning Approaches. J Biomed Phys Eng. 2022 Jun 1;12(3):297-308. https://doi.org/10.31661/jbpe.v0i0.2109-1403 · PMID: 35698545; PMCID: PMC9175124. DOI: https://doi.org/10.31661/jbpe.v0i0.2109-1403
4. Esteva, A., Robicquet, A., Ramsundar, B., Kuleshov, V., DePristo, M., Chou, K., ... & Dean, J. (2019). A guide to deep learning in healthcare. Nature Medicine, 25(1), 24-29. https://doi.org/10.1038/s41591-018-0316-z DOI: https://doi.org/10.1038/s41591-018-0316-z
5. LeCun, Y., Bengio, Y., & Hinton, G. (2015). Deep learning. Nature, 521(7553), 436-444. https://doi.org/10.1038/nature14539 DOI: https://doi.org/10.1038/nature14539
6. Uchikov P, Khalid U, Dedaj-Salad GH, Ghale D, Rajadurai H, Kraeva M, Kraev K, Hristov B, Doykov M, Mitova V, Bozhkova M, Markov S, Stanchev P. (2024). Artificial Intelligence in Breast Cancer Diagnosis and Treatment: Advances in Imaging, Pathology, and Personalized Care. Life (Basel). 8;14(11):1451. PMID: 39598249; PMCID: PMC11595975. https://doi.org/10.3390/life14111451 DOI: https://doi.org/10.3390/life14111451
7. Manali, D., Demirel, H., Eleyan, A. (2024). Deep Learning Based Breast Cancer Detection Using Decision Fusion. Computers, 13, 294. https://doi.org/10.3390/computers13110294 DOI: https://doi.org/10.3390/computers13110294
8. Korica, P., Gayar, N.E., Pang, W. (2021). Explainable Artificial Intelligence in Healthcare: Opportunities, Gaps and Challenges and a Novel Way to Look at the Problem Space. In: Yin, H., et al. Intelligent Data Engineering and Automated Learning – IDEAL 2021. IDEAL 2021. Lecture Notes in Computer Science, vol 13113. Springer, Cham. https://doi.org/10.1007/978-3-030-91608-4_33 DOI: https://doi.org/10.1007/978-3-030-91608-4_33
9. Hussain S, Ali M, Naseem U, Nezhadmoghadam F, Jatoi MA, Gulliver TA and Tamez-Peña JG (2024). Breast cancer risk prediction using machine learning: a systematic review. Front. Oncol. 14:1343627. https://doi.org/10.3389/fonc.2024.1343627 DOI: https://doi.org/10.3389/fonc.2024.1343627
10. Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., & Salakhutdinov, R. (2014). Dropout: A simple way to prevent neural networks from overfitting. Journal of Machine Learning Research, 15(1), 1929-1958. https://dl.acm.org/doi/abs/10.5555/2627435.2670313
11. Angelone, F.; Ponsiglione, A.M.; Ricciardi, C.; Belfiore, M.P.; Gatta, G.; Grassi, R.; Amato, F.; Sansone, M. (2024). A Machine Learning Approach for Breast Cancer Risk Prediction in Digital Mammography. Appl. Sci. 2024, 14, 10315. https://doi.org/10.3390/app142210315 DOI: https://doi.org/10.3390/app142210315
12. National Cancer Institute. (2020). SEER Cancer Statistics Review. Retrieved from https://seer.cancer.gov
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